Description

β-Nicotinamide adenine dinucleotide, a redox coenzyme central to cellular energy metabolism and a substrate for sirtuins, PARPs, and CD38. Because NAD+ declines with age, raising its availability is studied for effects on sirtuin signaling, DNA-repair enzyme activity, and mitochondrial function.

Key research notes:

• Supports mitochondrial & cellular energy metabolism
• Involved in sirtuin/PARP signaling & DNA repair
• Studied for age-related NAD+ decline
• Human IV pharmacokinetics characterized (Grant et al., 2019)

Specifications: CAS: 53-84-9 · Formula: C₂₁H₂₇N₇O₁₄P₂ · Molar mass: 663.43 g/mol · Form: Lyophilized powder · Storage: −20 °C; protect from moisture

Reconstitution: Add 5 mL BAC water → 100 mg/mL (100 mg = 100 units). A gentler prep: 10 mL → 50 mg/mL. Concentrated NAD+ is acidic and often diluted further.

Research dosing reference (reported in research, not usage instructions): Reported in research: a human PK study used 750 mg IV infused slowly over ~6 hours (Grant et al., 2019). Rapid concentrated administration is reported as poorly tolerated.

Research use only. Not for human consumption.