Description

A tripeptide (Lys-Pro-Val) — the C-terminal fragment of α-MSH — that retains anti-inflammatory activity without pigmentary effects. It is taken up by cells (via PepT1 in the gut) and reported to inhibit pro-inflammatory NF-κB and MAPK signaling.

Key research notes:

• Reduced intestinal inflammation in colitis models (Dalmasso et al., 2008)
• Anti-inflammatory via NF-κB/MAPK modulation
• Explored for skin & immune-mediated inflammation

Specifications: CAS: 67727-97-3 · Formula: C₁₆H₃₀N₄O₄ · Molar mass: 342.44 g/mol · Sequence: Lys-Pro-Val · Form: Lyophilized powder · Storage: −20 °C

Reconstitution: Add 2 mL BAC water → 5 mg/mL (250 mcg = 5 units; 0.5 mg = 10 units).

Research dosing reference (reported in research, not usage instructions): Reported in research: cell and rodent models — micromolar in-vitro and microgram-range delivery in murine colitis. No established human dosing.

Research use only. Not for human consumption.